克氏锥虫的信号传导与宿主细胞入侵

Signaling and host cell invasion by Trypanosoma cruzi.

作者信息

Burleigh B A, Andrews N W

机构信息

Department of Cell Biology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8002, USA.

出版信息

Curr Opin Microbiol. 1998 Aug;1(4):461-5. doi: 10.1016/s1369-5274(98)80066-0.

DOI:10.1016/s1369-5274(98)80066-0

PMID:10066513

Abstract

Signal transduction events triggered in mammalian host cells by the obligate intracellular parasite Trypanosoma cruzi are required for invasion. Infective T. cruzi trypomastigotes elicit Ca2+ signaling in mammalian host cells and activate transforming growth factor-beta receptor signaling pathways. The elevation of Ca2+ in T. cruzi, induced by host-cell contact, is also required for invasion, extending the concept of host-pathogen 'cross-talk' to invasive protozoan pathogens.

摘要

专性细胞内寄生虫克氏锥虫在哺乳动物宿主细胞中引发的信号转导事件是入侵所必需的。感染性克氏锥虫锥鞭毛体在哺乳动物宿主细胞中引发Ca2+信号，并激活转化生长因子-β受体信号通路。宿主细胞接触诱导克氏锥虫中Ca2+的升高对于入侵也是必需的，这将宿主-病原体“相互作用”的概念扩展到侵袭性原生动物病原体。