Gasbarrini A, Serricchio M, Tondi P, Franceschi F, Ojetti V, Sanz Torre E, Candelli M, Gabrielli M, Fiore G, Pola R, Santoliquido A, Giacovazzo M, Gasbarrini G, Pola P
Internal Medicine Department, Catholic University of Rome, Italy.
Ital J Gastroenterol Hepatol. 1998 Oct;30 Suppl 3:S307-9.
Helicobacter pylori infection has recently been associated to some organic functional vascular disorders and, both observational and interventional studies have been carried out. A correlation between Helicobacter pylori infection and ischaemic heart disease was first described in 1994. Recent data, moreover, indicate a role of the bacterium in some functional vascular disorders such as primary headache and primary Raynaud phenomenon; indeed, some patients following eradication of Helicobacter pylori showed a significant improvement in the manifestations of these diseases. The host immune response against the bacterium may play an important role in the pathogenesis of vascular disorders, probably through a chronic stimulation of the release of vasoactive substances, such as cytokines, prostaglandins and others. However, various confounding factors such as co-infections, genetic and immunological host-factors, different strains of Helicobacter pylori or other may influence the data. Well designed case/control and randomized interventional studies are still needed to assess the real role of Helicobacter pylori in vascular disorders.
幽门螺杆菌感染最近与一些器质性功能性血管疾病相关，并且已经开展了观察性和干预性研究。幽门螺杆菌感染与缺血性心脏病之间的相关性最早于1994年被描述。此外，最近的数据表明该细菌在一些功能性血管疾病中发挥作用，如原发性头痛和原发性雷诺现象；事实上，一些幽门螺杆菌根除后的患者这些疾病的表现有显著改善。宿主针对该细菌的免疫反应可能在血管疾病的发病机制中起重要作用，可能是通过对血管活性物质如细胞因子、前列腺素等释放的慢性刺激。然而，各种混杂因素如合并感染、宿主的遗传和免疫因素、不同的幽门螺杆菌菌株或其他因素可能会影响数据。仍需要设计良好的病例/对照和随机干预研究来评估幽门螺杆菌在血管疾病中的真正作用。
