大鼠大脑中神经肽分布的性别差异。

Sex differences in neuropeptide distribution in the rat brain.

作者信息

Rugarn O, Hammar M, Theodorsson A, Theodorsson E, Stenfors C

机构信息

Division of Obstetrics and Gynecology, Faculty of Health Sciences, Linköping University, Sweden.

出版信息

Peptides. 1999;20(1):81-6. doi: 10.1016/s0196-9781(98)00139-9.

DOI:10.1016/s0196-9781(98)00139-9

PMID:10098627

Abstract

We have investigated possible sex differences in the regional concentrations of neuropeptides in the rat brain. Immunoreactive neurotensin (NT), neurokinin A (NKA), galanin (GAL), calcitonin gene-related peptide (CGRP), substance P (SP) and neuropeptide Y (NPY) were measured by radioimmunoassay in frontal cortex, occipital cortex, hippocampus, striatum, hypothalamus and pituitary in male and female pre- and postpubertal rats. Sex differences were found for NPY (p < 0.001), NT (p < 0.01) and GAL (p < 0.05), in particular in hippocampus, striatum, hypothalamus and pituitary, but not for CGRP, SP and NKA. Results from analysis of neuropeptides in one sex may not be entirely applicable to the other.

摘要

我们研究了大鼠脑中神经肽区域浓度可能存在的性别差异。采用放射免疫分析法测定了雄性和雌性青春期前及青春期后大鼠额叶皮质、枕叶皮质、海马体、纹状体、下丘脑和垂体中免疫反应性神经降压素（NT）、神经激肽A（NKA）、甘丙肽（GAL）、降钙素基因相关肽（CGRP）、P物质（SP）和神经肽Y（NPY）的含量。发现NPY（p<0.001）、NT（p<0.01）和GAL（p<0.05）存在性别差异，尤其在海马体、纹状体、下丘脑和垂体中，但CGRP、SP和NKA不存在性别差异。对一种性别的神经肽分析结果可能并不完全适用于另一种性别。