Wesseling K H, Purschke R, Smith N T, Wüst H J, de Wit B, Weber H A
Acta Anaesthesiol Belg. 1976;27 suppl:327-41.
A new pulse contour method to determine stroke volume and cardiac output continuously in patients on a beat-to-beat basis from the aortic pressure wave has been implemented in the form of a simple, inexpensive, fully automatic computing module for a commercially available patients monitoring system (Philips Medical Systems). Its reliability has been tested and shown in a computer analog, in experimental studies in 10 dogs (not reported here), in 22 hemodynamic studies on 20 young healthy volunteers and during 41 days in 20 postsurgical patients in the ICU, the most important result being that erros figures (15 and 19% respectively in the two human studies) are of the same order as when two standard methods, Fick and dye dilution are compared. The clinical studies have further indicated the easy applicability of the module 1 degree in the monitoring of critically ill patients in ICU's, 2 degrees as a monitor of the systemic circulation during anesthesia, and 3 degrees as a tool for studying the hemodynamic effects of pharmacological agents. The instrument consitutes no burden to the patients and has, several times during the course of the evaluation, provided an early warning of a deteriorating hemodynamic status of the patient to the physician.
一种新的脉搏轮廓法可根据主动脉压力波逐搏连续测定患者的每搏输出量和心输出量,该方法已被制成一个简单、廉价的全自动计算模块,用于市售的患者监测系统(飞利浦医疗系统公司)。其可靠性已在计算机模拟、对10只狗的实验研究(此处未报告)、对20名年轻健康志愿者的22项血流动力学研究以及对20名重症监护病房术后患者长达41天的监测中得到测试和验证,最重要的结果是误差值(两项人体研究中分别为15%和19%)与比较两种标准方法(Fick法和染料稀释法)时的误差值处于同一水平。临床研究进一步表明,该模块具有以下优点:一是在重症监护病房对重症患者进行监测时易于应用;二是在麻醉期间可作为体循环的监测工具;三是可作为研究药物血流动力学效应的工具。该仪器不会给患者带来负担,并且在评估过程中多次向医生发出患者血流动力学状态恶化的早期预警。