萘并[1,2 - b]呋喃、呋喃并[2,3 - f]、呋喃并[2,3 - g]和呋喃并[3,2 - g]喹啉衍生物的体外细胞毒性活性
In vitro cytotoxic activity of naphtho[1,2-b]furan, furo[2,3-f], furo[2,3-g] and furo[3,2-g]quinoline derivatives.
作者信息
Nebois P, Cherkaoui O, Benameur L, Boitard M, Bartoli M H, Fillion H
机构信息
Laboratoire de Chimie Organique, Institut des Sciences Pharmaceutiques et Biologiques, Lyon, France.
出版信息
Pharmazie. 1999 Mar;54(3):215-8.
PMID:10192109
Abstract
Some naphtho[1,2-b]furan, furo[2,3-f], furo[2,3-g] and furo[3,2-g]quinoline derivatives have been submitted to in vitro cytotoxic tests towards L 1210, MDA-MB 231 and PC3 cell lines. Among them, the furoquinone structures exhibited the most interesting IC50 values.
摘要
一些萘并[1,2 - b]呋喃、呋喃[2,3 - f]、呋喃[2,3 - g]和呋喃[3,2 - g]喹啉衍生物已针对L 1210、MDA - MB 231和PC3细胞系进行了体外细胞毒性测试。其中，呋喃醌结构表现出最有趣的半数抑制浓度（IC50）值。
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