Husbands S M, Breeden S W, Grivas K, Lewis J W
School of Chemistry, Cantock's Close, University of Bristol, England.
Bioorg Med Chem Lett. 1999 Mar 22;9(6):831-4. doi: 10.1016/s0960-894x(99)00085-2.
A series of furanomorphides were synthesised as ring-constrained analogues of buprenorphine and related orvinols. Evaluation in binding and functional assays has shown that the furanomorphides have reduced efficacy at the mu opioid receptor compared to the orvinols.
合成了一系列呋喃吗啡类化合物作为丁丙诺啡及相关奥维诺醇的环约束类似物。结合和功能测定评估表明，与奥维诺醇相比，呋喃吗啡类化合物对μ阿片受体的效力降低。
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