伴有严重肥胖、胰岛素抵抗和甲状腺功能减退的黑棘皮病：通过饮食控制改善

Acanthosis nigricans with severe obesity, insulin resistance and hypothyroidism: improvement by diet control.

作者信息

Kuroki R, Sadamoto Y, Imamura M, Abe Y, Higuchi K, Kato K, Koga T, Furue M

机构信息

Division of Dermatology, National Kokura Hospital, Kitakyushu, Japan.

出版信息

Dermatology. 1999;198(2):164-6. doi: 10.1159/000018096.

DOI:10.1159/000018096

PMID:10325466

Abstract

We report on a 27-year-old man with acanthosis nigricans (AN) associated with severe obesity, insulin resistance and hypothyroidism. A very low-calorie diet treatment decreased his weight and then ameliorated the insulin-resistant state. These effects were followed by remarkable improvement of the AN prior to the correction of the hypothyroidism. This confirms that AN may be mainly attributed to insulin resistance rather than hypothyroidism per se.

摘要

我们报告了一名27岁男性，患有黑棘皮病（AN），伴有严重肥胖、胰岛素抵抗和甲状腺功能减退。极低热量饮食治疗使他体重减轻，进而改善了胰岛素抵抗状态。在甲状腺功能减退得到纠正之前，这些效应伴随着AN的显著改善。这证实了AN可能主要归因于胰岛素抵抗，而非甲状腺功能减退本身。