促肾上腺皮质激素与氨己烯酸治疗婴儿痉挛症的回顾性研究

ACTH versus vigabatrin therapy in infantile spasms: a retrospective study.

作者信息

Cossette P, Riviello J J, Carmant L

机构信息

Department of Pediatrics (Neurology), Université de Montréal, Hôpital Sainte-Justine, Québec, Canada.

出版信息

Neurology. 1999 May 12;52(8):1691-4. doi: 10.1212/wnl.52.8.1691.

DOI:10.1212/wnl.52.8.1691

PMID:10331702

Abstract

ACTH is the standard treatment for infantile spasms (IS) in North America. Recent reports showed that vigabatrin is a valuable treatment for IS, but comparative studies with ACTH are limited. In this study, we compare the effectiveness of ACTH versus vigabatrin on IS. Our results support that vigabatrin is as effective as and better tolerated than ACTH. Because of their similar efficacy, we believe that vigabatrin should be the first intention drug for the treatment of IS.

摘要

促肾上腺皮质激素（ACTH）是北美治疗婴儿痉挛症（IS）的标准疗法。最近的报告显示，vigabatrin是治疗IS的一种有效疗法，但与ACTH的对比研究有限。在本研究中，我们比较了ACTH和vigabatrin治疗IS的有效性。我们的结果支持vigabatrin与ACTH疗效相当且耐受性更好。由于它们疗效相似，我们认为vigabatrin应作为治疗IS的首选药物。