Simpson D D, Joe G W, Fletcher B W, Hubbard R L, Anglin M D
Institute of Behavioral Research, Texas Christian University, Fort Worth 76129, USA.
Arch Gen Psychiatry. 1999 Jun;56(6):507-14. doi: 10.1001/archpsyc.56.6.507.
This national study focused on posttreatment outcomes of community treatments of cocaine dependence. Relapse to weekly (or more frequent) cocaine use in the first year after discharge from 3 major treatment modalities was examined in relation to patient problem severity at admission to the treatment program and length of stay.
We studied 1605 cocaine-dependent patients from 11 cities located throughout the United States using a naturalistic, nonexperimental evaluation design. They were sequentially admitted from November 1991 to December 1993 to 55 community-based treatment programs in the national Drug Abuse Treatment Outcome Studies. Included were 542 patients admitted to 19 long-term residential programs, 458 patients admitted to 24 outpatient drug-free programs, and 605 patients admitted to 12 short-term inpatient programs.
Of 1605 patients, 377 (23.5%) reported weekly cocaine use in the year following treatment (dropping from 73.1% in the year before admission). An additional 18.0% had returned to another drug treatment program. Higher severity of patient problems at program intake and shorter stays in treatment (<90 days) were related to higher cocaine relapse rates.
Patients with the most severe problems were more likely to enter long-term residential programs, and better outcomes were reported by those treated 90 days or longer. Dimensions of psychosocial problem severity and length of stay are, therefore, important considerations in the treatment of cocaine dependence. Cocaine relapse rates for patients with few problems at program intake were most favorable across all treatment conditions, but better outcomes for patients with medium- to high-level problems were dependent on longer treatment stays.
这项全国性研究聚焦于可卡因依赖社区治疗的治疗后结果。研究了从三种主要治疗方式出院后的第一年中,每周(或更频繁)使用可卡因的复发情况与治疗项目入院时患者问题严重程度及住院时间的关系。
我们采用自然主义、非实验性评估设计,对来自美国各地11个城市的1605名可卡因依赖患者进行了研究。他们于1991年11月至1993年12月依次被纳入全国药物滥用治疗结果研究中的55个社区治疗项目。其中包括19个长期住院项目收治的542名患者、24个门诊戒毒项目收治的458名患者以及12个短期住院项目收治的605名患者。
在1605名患者中,377名(23.5%)报告在治疗后的一年中每周使用可卡因(入院前一年这一比例为73.1%)。另外18.0%的患者返回了另一个药物治疗项目。项目入院时患者问题严重程度较高以及治疗时间较短(<90天)与可卡因复发率较高相关。
问题最严重的患者更有可能进入长期住院项目,接受90天或更长时间治疗的患者报告的结果更好。因此,心理社会问题严重程度和住院时间维度是治疗可卡因依赖时的重要考虑因素。在所有治疗条件下,项目入院时问题较少的患者可卡因复发率最有利,但中高水平问题患者的更好结果依赖于更长的治疗时间。