荷兰队列研究中动物产品、钙和蛋白质与前列腺癌风险的关系
Animal products, calcium and protein and prostate cancer risk in The Netherlands Cohort Study.
作者信息
Schuurman A G, van den Brandt P A, Dorant E, Goldbohm R A
机构信息
Department of Epidemiology, Maastricht University, The Netherlands.
出版信息
Br J Cancer. 1999 Jun;80(7):1107-13. doi: 10.1038/sj.bjc.6690472.
Prostate cancer risk in relation to consumption of animal products, and intake of calcium and protein was investigated in the Netherlands Cohort Study. At baseline in 1986, 58,279 men aged 55-69 years completed a self-administered 150-item food frequency questionnaire and a questionnaire on other risk factors for cancer. After 6.3 years of follow-up, 642 prostate cancer cases were available for analysis. In multivariate case-cohort analyses adjusted for age, family history of prostate cancer and socioeconomic status, no associations were found for consumption of fresh meat, fish, cheese and eggs. Positive trends in risk were found for consumption of cured meat and milk products (P-values 0.04 and 0.02 respectively). For calcium and protein intake, no associations were observed. The hypothesis that dietary factors might be more strongly related to advanced prostate tumours could not be confirmed in our study. We conclude that, in this study, animal products are not strongly related to prostate cancer risk.
在荷兰队列研究中，对动物产品的消费以及钙和蛋白质的摄入量与前列腺癌风险之间的关系进行了调查。1986年基线时，58279名年龄在55至69岁之间的男性完成了一份150项的自填式食物频率问卷以及一份关于其他癌症风险因素的问卷。经过6.3年的随访，有642例前列腺癌病例可供分析。在针对年龄、前列腺癌家族史和社会经济地位进行调整的多变量病例队列分析中，未发现新鲜肉类、鱼类、奶酪和鸡蛋的消费与前列腺癌之间存在关联。腌制肉类和奶制品的消费呈现出风险增加的趋势（P值分别为0.04和0.02）。对于钙和蛋白质的摄入量，未观察到关联。饮食因素可能与晚期前列腺肿瘤更密切相关这一假设在我们的研究中未得到证实。我们得出结论，在本研究中，动物产品与前列腺癌风险没有密切关系。
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