青蒿烯的微生物代谢

Microbial metabolism of artemisitene.

作者信息

Orabi K Y, Galal A M, Ibrahim A R, el-Feraly F S, Khalifa S I, el-Sohly H N

机构信息

Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

出版信息

Phytochemistry. 1999 May;51(2):257-61. doi: 10.1016/s0031-9422(98)00770-5.

DOI:10.1016/s0031-9422(98)00770-5

PMID:10365449

Abstract

Studies on the microbial transformation of the sesquiterpene endoperoxide artemisitene have revealed that artemisitene was metabolized by Aspergillus niger (NRRL 599) to yield 11-epi-artemisinin, 9 beta-hydroxydeoxy-11-epi-artemisinin and 9 beta-hydroxy-11-epi-artemisinnin. These metabolites were characterized on the basis of their spectral data.

摘要

对倍半萜内过氧化物青蒿烯的微生物转化研究表明，青蒿烯被黑曲霉（NRRL 599）代谢，生成11-表青蒿素、9β-羟基脱氧-11-表青蒿素和9β-羟基-11-表青蒿素。这些代谢产物根据其光谱数据进行了表征。