通过包封于聚（D，L-丙交酯）纳米颗粒提高2'，6'-二羟基-4'-甲氧基查耳酮的体外和体内抗利什曼原虫活性。
Improvement of in vitro and in vivo antileishmanial activities of 2', 6'-dihydroxy-4'-methoxychalcone by entrapment in poly(D,L-lactide) nanoparticles.
作者信息
Torres-Santos E C, Rodrigues J M, Moreira D L, Kaplan M A, Rossi-Bergmann B
机构信息
Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
出版信息
Antimicrob Agents Chemother. 1999 Jul;43(7):1776-8. doi: 10.1128/AAC.43.7.1776.
Abstract
The inhibition of intracellular Leishmania amazonensis growth by 2', 6'-dihydroxy-4'-methoxychalcone (DMC) isolated from Piper aduncum was further enhanced after encapsulation of DMC in polymeric nanoparticles. Encapsulated DMC also showed increased antileishmanial activity in infected BALB/c mice, as evidenced by significantly smaller lesions and fewer parasites in the lesions.
摘要
从南美胡椒中分离出的2',6'-二羟基-4'-甲氧基查耳酮（DMC）对细胞内亚马逊利什曼原虫生长具有抑制作用，将DMC包裹于聚合物纳米颗粒后，其抑制作用进一步增强。包裹后的DMC在感染的BALB/c小鼠中也表现出增强的抗利什曼原虫活性，表现为病变显著更小且病变内的寄生虫数量更少。
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