胃肠外给予神经节苷脂与吉兰-巴雷综合征之间的关系

[Relationship between parenteral gangliosides administration and the Guillain-Barré syndrome].

作者信息

Conceição I, Carvalho M, Alves M, Parreira E, Martins A, Ferro J, Sales-Luis M L

机构信息

Servicio de Neurología, Hospital de Santa Maria, Lisboa, Portugal.

出版信息

Rev Neurol. 1999;28(11):1033-5.

PMID:10390766

Abstract

OBJECTIVE

We carried out a case a case-control study to analyze the relationship between parenteral gangliosides administration and the Guillain-Barré syndrome.

PATIENTS AND METHODS

We retrieved 64 patients with the diagnosis of Guillain-Barré syndrome, and 148 controls. In cases and controls the proportion and 95% confidence intervals (CI) of subject receiving gangliosides, was calculated. The number of patients with the Guillain-Barré syndrome who needed ventilation or died was also calculated.

RESULTS

Four of 36 patients (95% CI = 81-0.6), over 40 years, received gangliosides prior to Guillain-Barré syndrome. One of these patients was ventilated (95% CI = 25-2) and died. None of the controls less than 40 years old took gangliosides, while from the 108 over 40 (95% CI = 15-4) 9 received gangliosides. None developed signs suggesting Guillain-Barré syndrome. Although gangliosides were more often used in Guillain-Barré syndrome (OR = 1.75), the difference was not significant (95% CI = 4.82-0.69).

CONCLUSION

The present work proves that in spite of the association of Guillain-Barré syndrome, with gangliosides intake, there is no statistical difference between this group of patients and control population.

摘要

目的

我们开展了一项病例对照研究，以分析胃肠外给予神经节苷脂与吉兰 - 巴雷综合征之间的关系。

患者与方法

我们检索出64例诊断为吉兰 - 巴雷综合征的患者以及148例对照。计算了病例组和对照组中接受神经节苷脂治疗的受试者比例及95%置信区间（CI）。还计算了需要通气或死亡的吉兰 - 巴雷综合征患者数量。

结果

36例40岁以上的患者中有4例（95% CI = 81 - 0.6）在患吉兰 - 巴雷综合征之前接受了神经节苷脂治疗。其中1例患者需要通气（95% CI = 25 - 2）并死亡。40岁以下的对照组中无人服用神经节苷脂，而在108例40岁以上的患者（95% CI = 15 - 4）中有9例接受了神经节苷脂治疗。无人出现提示吉兰 - 巴雷综合征的体征。尽管神经节苷脂在吉兰 - 巴雷综合征患者中使用更为频繁（比值比 = 1.75），但差异无统计学意义（95% CI = 4.82 - 0.69）。