少突胶质细胞瘤中的基因畸变：一项使用比较基因组杂交（CGH）的分析。

Genetic aberrations in oligodendroglial tumours: an analysis using comparative genomic hybridization (CGH).

作者信息

Kros J M, van Run P R, Alers J C, Beverloo H B, van den Bent M J, Avezaat C J, van Dekken H

机构信息

Department of Pathology, University Hospital Rotterdam-Dijkzigt, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.

出版信息

J Pathol. 1999 Jul;188(3):282-8. doi: 10.1002/(SICI)1096-9896(199907)188:3<282::AID-PATH355>3.0.CO;2-S.

DOI:10.1002/(SICI)1096-9896(199907)188:3<282::AID-PATH355>3.0.CO;2-S

PMID:10419597

Abstract

Four low-grade oligodendrogliomas, nine anaplastic oligodendrogliomas and two mixed oligoastrocytomas were investigated for chromosomal aberrations by comparative genomic hybridization on formalin-fixed, paraffin-embedded tissue samples. The most frequent losses observed involved 1p, 9p, 10pq, 14q, 16p, 19q, while the most frequent gains were seen on 7pq, 11pq, 17p, 19pq, and Xp. In one oligodendroglioma, a highly specific amplification of 1q32.1 was seen. The frequent losses of 14q have not been reported previously. In the two cases of mixed oligoastrocytomas multiple gains and losses were found that did not show a clear overlap with the alterations found in the pure oligodendrogliomas.

摘要

对4例低级别少突胶质细胞瘤、9例间变性少突胶质细胞瘤和2例混合性少突星形细胞瘤，采用比较基因组杂交技术，在福尔马林固定、石蜡包埋的组织样本上研究染色体畸变情况。观察到最常见的缺失涉及1p、9p、10pq、14q、16p、19q，而最常见的增益出现在7pq、11pq、17p、19pq和Xp。在1例少突胶质细胞瘤中，发现1q32.1高度特异性扩增。14q的频繁缺失此前未见报道。在2例混合性少突星形细胞瘤中，发现了多个增益和缺失，与纯少突胶质细胞瘤中发现的改变没有明显重叠。