蛋白激酶抑制剂的研发及其治疗潜力

The development and therapeutic potential of protein kinase inhibitors.

作者信息

Cohen P

机构信息

MRC Protein Phosphorylation Unit, Department of Biochemistry, MSI/WTB Complex, Dow Street, University of Dundee, Dundee, DD1 5EH, Scotland, UK.

出版信息

Curr Opin Chem Biol. 1999 Aug;3(4):459-65. doi: 10.1016/S1367-5931(99)80067-2.

DOI:10.1016/S1367-5931(99)80067-2

PMID:10419844

Abstract

A number of small cell-permeant protein kinase inhibitors have been developed that have the potential for treating a variety of diseases. The basis for the specificity of several of these drugs has been elucidated and a number are undergoing human clinical trials.

摘要

已经开发出多种可透过细胞的小分子蛋白激酶抑制剂，它们具有治疗多种疾病的潜力。其中几种药物的特异性基础已得到阐明，并且有一些正在进行人体临床试验。