用于植入式静脉装置（输液港）感染抗生素封管治疗的抗生素稳定性
Stability of antibiotics used for antibiotic-lock treatment of infections of implantable venous devices (ports).
作者信息
Anthony T U, Rubin L G
机构信息
Division of Infectious Diseases, Department of Pediatrics, Schneider Children's Hospital of Long Island Jewish Medical Center, New Hyde Park, New York 11040, USA.
出版信息
Antimicrob Agents Chemother. 1999 Aug;43(8):2074-6. doi: 10.1128/AAC.43.8.2074.
Abstract
Antibiotic-lock is a treatment for catheter-related bloodstream infections in which a solution containing heparin and an antibiotic dwells in the lumen of the catheter or port. We tested the stability of vancomycin, cefazolin, ticarcillin-clavulanic acid, ceftazidime, or ciprofloxacin combined with heparin after incubation in vitro at 25 or 37 degrees C for intervals of up to 10 days by bioassay. All the antibiotic solutions except ceftazidime retained >/=90% activity at both 25 and 37 degrees C. Thus, studies of antibiotic-heparin lock solutions with dwell times of up to 10 days are feasible.
摘要
抗生素封管是一种治疗导管相关血流感染的方法，即含有肝素和抗生素的溶液留置在导管或端口的管腔内。我们通过生物测定法，测试了万古霉素、头孢唑林、替卡西林-克拉维酸、头孢他啶或环丙沙星与肝素在25℃或37℃体外孵育长达10天的间隔时间后的稳定性。除头孢他啶外，所有抗生素溶液在25℃和37℃时均保持≥90%的活性。因此，对抗生素-肝素封管溶液进行长达10天的留置时间研究是可行的。
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