Rae C P, Mansfield M D, Dryden C, Kinsella J
University Department of Anaesthesia, Glasgow Royal Infirmary University NHS Trust, UK.
Br J Anaesth. 1999 Mar;82(3):427-8. doi: 10.1093/bja/82.3.427.
This study was designed to measure ischaemic pain during and after infusion of adenosine. In a double-blind, placebo-controlled, crossover study, eight ASA 1 male volunteers received infusion of adenosine 100 micrograms kg-1 min-1 or placebo for 10 min. This was repeated 1 week later with the alternate infusion. Pain measurements were made during tourniquet-induced ischaemia in an exercising arm before infusion, during infusion and for 24 h afterwards. Pain was reduced significantly in the adenosine group compared with the saline group during infusion (median difference 20.8; 95% confidence interval 2.0-40). There was no significant difference in pain after infusion and there were no significant changes in cardiovascular variables. During infusion of adenosine, transient mild chest discomfort, shortness of breath and facial flushing occurred. We conclude that adenosine had measurable effects on ischaemic pain which were not sustained after discontinuation of infusion.
本研究旨在测量腺苷输注期间及之后的缺血性疼痛。在一项双盲、安慰剂对照的交叉研究中，8名ASA 1级男性志愿者接受了100微克/千克/分钟的腺苷输注或安慰剂输注，持续10分钟。1周后进行交替输注，重复上述操作。在输注前、输注期间以及之后24小时，对运动手臂上止血带诱导的缺血过程中的疼痛进行测量。与生理盐水组相比，腺苷组在输注期间疼痛显著减轻（中位数差异20.8；95%置信区间2.0 - 40）。输注后疼痛无显著差异，心血管变量也无显著变化。在腺苷输注期间，出现了短暂的轻度胸部不适、呼吸急促和面部潮红。我们得出结论，腺苷对缺血性疼痛有可测量的影响，但在输注停止后这种影响并不持续。
