痤疮：免疫和微生物学因素综述
Acne: a review of immunologic and microbiologic factors.
作者信息
Burkhart C G, Burkhart C N, Lehmann P F
机构信息
Department of Medicine, Medical College of Ohio, Toledo, USA.
出版信息
Postgrad Med J. 1999 Jun;75(884):328-31. doi: 10.1136/pgmj.75.884.328.
Abstract
Acne vulgaris is a self-limiting skin disorder seen primarily in adolescents, whose aetiology appears to be multifactorial. The four main aetiological factors are hypercornification of the pilosebaceous duct, increased sebum production, colonization with Propionibacterium acnes, and subsequently the production of inflammation. Considerable investigation has addressed the immunologic reaction to extracellular products produced by the acne-causing organism, P acnes. The immunologic response involves both humoral and cell-mediated pathways. Further research should clarify the role of complement, cytotoxins, and neutrophils in this acne-forming response.
摘要
寻常痤疮是一种主要见于青少年的自限性皮肤病，其病因似乎是多因素的。四个主要病因是皮脂腺导管过度角化、皮脂分泌增加、痤疮丙酸杆菌定植以及随后产生炎症。大量研究关注了对致痘微生物痤疮丙酸杆菌产生的细胞外产物的免疫反应。免疫反应涉及体液和细胞介导途径。进一步的研究应阐明补体、细胞毒素和中性粒细胞在这种痤疮形成反应中的作用。
相似文献
1
Acne: a review of immunologic and microbiologic factors.
Postgrad Med J. 1999 Jun;75(884):328-31. doi: 10.1136/pgmj.75.884.328.
2
[Skin reactions to antigens of propionibacterium acnes in patients with acne vulgaris treated with autovaccine].
Ann Acad Med Stetin. 1998;44:65-85.
3
The pathogenesis of acne.
Acta Dermatovenerol Croat. 2005;13(1):44-9.
4
Increased interferon-gamma, interleukin-12p40 and IL-8 production in Propionibacterium acnes-treated peripheral blood mononuclear cells from patient with acne vulgaris: host response but not bacterial species is the determinant factor of the disease.
J Dermatol Sci. 2009 Jul;55(1):47-52. doi: 10.1016/j.jdermsci.2009.02.015. Epub 2009 Apr 17.
5
6
Prospects of acne vaccines targeting secreted virulence factors of Cutibacterium acnes.
Expert Rev Vaccines. 2019 May;18(5):433-437. doi: 10.1080/14760584.2019.1593830. Epub 2019 Mar 28.
7
Does inflammatory acne result from imbalance in the keratinocyte innate immune response?
Microbes Infect. 2010 Dec;12(14-15):1085-90. doi: 10.1016/j.micinf.2010.07.015. Epub 2010 Aug 5.
8
The role of innate immunity in the pathogenesis of acne.
Dermatology. 2003;206(2):96-105. doi: 10.1159/000068476.
9
Assessment of etiologic agents in acne pathogenesis.
Skinmed. 2003 Jul-Aug;2(4):222-8. doi: 10.1111/j.1540-9740.2003.02134.x.
10
[Cytotoxicity in acne vulgaris].
Med Cutan Ibero Lat Am. 1982;10(1):31-6.
引用本文的文献
1
Gedunin Mitigates -Induced Skin Inflammation by Inhibiting the NF-κB Pathway.
Pharmaceuticals (Basel). 2025 Jan 9;18(1):71. doi: 10.3390/ph18010071.
2
No genetic causal relationship between acne and prostate cancer through Mendelian randomization combined with meta-analysis.
Front Oncol. 2024 Sep 19;14:1460467. doi: 10.3389/fonc.2024.1460467. eCollection 2024.
3
A Novel Treatment of Acne Vulgaris Using a 1927 nm Fractional Thulium Laser: A Case Series.
Clin Cosmet Investig Dermatol. 2024 Aug 27;17:1931-1942. doi: 10.2147/CCID.S468326. eCollection 2024.
4
Skin Microbiome, Metabolome and Skin Phenome, from the Perspectives of Skin as an Ecosystem.
Phenomics. 2022 Oct 10;2(6):363-382. doi: 10.1007/s43657-022-00073-y. eCollection 2022 Dec.
5
Antimicrobial Activity of Gelatin Nanofibers Enriched by Essential Oils against and .
Nanomaterials (Basel). 2023 Feb 24;13(5):844. doi: 10.3390/nano13050844.
6
Comparative lipidomic profiling of the human commensal bacterium and its extracellular vesicles.
RSC Adv. 2018 Apr 23;8(27):15241-15247. doi: 10.1039/c7ra13769a. eCollection 2018 Apr 18.
7
Infection Induces Type I Interferon Synthesis Through the cGAS-STING Pathway.
Front Immunol. 2020 Oct 15;11:571334. doi: 10.3389/fimmu.2020.571334. eCollection 2020.
8
The Skin Microbiota: Balancing Risk and Reward.
Cell Host Microbe. 2020 Aug 12;28(2):190-200. doi: 10.1016/j.chom.2020.06.017.
9
Topical benzoyl peroxide for acne.
Cochrane Database Syst Rev. 2020 Mar 16;3(3):CD011154. doi: 10.1002/14651858.CD011154.pub2.
10
Antimicrobial activity of certain natural-based plant oils against the antibiotic-resistant acne bacteria.
Saudi J Biol Sci. 2020 Jan;27(1):448-455. doi: 10.1016/j.sjbs.2019.11.006. Epub 2019 Nov 20.
本文引用的文献
1
The role of Malassezia species in the ecology of human skin and as pathogens.
Med Mycol. 1998;36 Suppl 1:220-9.
2
IgG subclasses specific to Staphylococcus epidermidis and Propionibacterium acnes in patients with acne vulgaris.
Br J Dermatol. 1997 May;136(5):730-3.
3
4
Delayed skin test reactivity to Propionibacterium acnes correlates with severity of inflammation in acne vulgaris.
Br J Dermatol. 1980 Dec;103(6):651-5. doi: 10.1111/j.1365-2133.1980.tb01687.x.
5
Cytotaxin production by comedonal bacteria (Propionibacterium acnes, Propionibacterium granulosum and Staphylococcus epidermidis).
J Invest Dermatol. 1980 Jan;74(1):36-9. doi: 10.1111/1523-1747.ep12514592.
6
Inflammation in acne vulgaris: leukocyte attraction and cytotoxicity by comedonal material.
J Invest Dermatol. 1980 Jan;74(1):21-5. doi: 10.1111/1523-1747.ep12514573.
7
Natural killer (NK) cells and their possible roles in resistance against disease.
Clin Immunol Rev. 1981;1(1):1-65.
8
Lympho-reticular stimulatory properties of Corynebacterium parvum and related bacteria.
J Med Microbiol. 1973 Aug;6(3):261-74. doi: 10.1099/00222615-6-3-261.
9
The localization and distribution of Corynebacterium acnes and its antigens in normal skin and in lesions of acne vulgaris.
J Invest Dermatol. 1969 Aug;53(2):143-50. doi: 10.1038/jid.1969.120.
10
Dermal hypersensitivity of patients with acne vulgaris to Corynebacterium acnes.
J Invest Dermatol. 1967 Aug;49(2):154-8. doi: 10.1038/jid.1967.118.
Zotero 插件