人类免疫缺陷病毒1型与抗原呈递细胞的相互作用。

Interactions of HIV-1 with antigen-presenting cells.

作者信息

Hewson T, Lone N, Moore M, Howie S

机构信息

Department of Pathology, University of Edinburgh Medical School, Edinburgh, United Kingdom.

出版信息

Immunol Cell Biol. 1999 Aug;77(4):289-303. doi: 10.1046/j.1440-1711.1999.00833.x.

DOI:10.1046/j.1440-1711.1999.00833.x

PMID:10457195

Abstract

There is currently much interest in the numerical and functional loss of antigen-presenting cells (APC) in HIV-1 disease and the contribution that this may make to HIV-1 pathology. The HIV-1 virus can interfere with the normal function of APC in a number of ways involving inappropriate signalling. These include changes in cytokine balance, cell-surface molecule expression and intracellular signalling pathways. This review examines how HIV-1 is able to disregulate APC function and discusses possible outcomes for the function of the immune system.

摘要

目前，人们对HIV-1疾病中抗原呈递细胞（APC）的数量和功能丧失以及这可能对HIV-1病理学产生的影响非常感兴趣。HIV-1病毒可通过多种涉及不适当信号传导的方式干扰APC的正常功能。这些包括细胞因子平衡、细胞表面分子表达和细胞内信号通路的变化。本综述探讨了HIV-1如何能够破坏APC功能，并讨论了免疫系统功能的可能结果。