Noonan S S
N J Med. 1999 Aug;96(8):23-5.
As recently as the 1970s, sickle cell anemia patients had little hope of living past their teen years and little relief from painful crises. With the 1980s came the use of prophylactic penicillin to significantly reduce morbidity and mortality from infection in sickle cell youngsters. One of the sickle cell breakthroughs of the 1990s is the use of hydroxyurea for sickle cell treatment in adult patients. In the future, gene therapy may be the answer to the complex problems sickle cell anemia presents.
就在20世纪70年代,镰状细胞贫血患者活到十几岁的希望渺茫,也几乎无法缓解痛苦的危机。到了20世纪80年代,预防性使用青霉素显著降低了镰状细胞病青少年感染的发病率和死亡率。20世纪90年代镰状细胞病的突破之一是使用羟基脲治疗成年镰状细胞病患者。未来,基因疗法可能是解决镰状细胞贫血所带来的复杂问题的答案。