Eckel L A, Geary N
Joan and Sanford I. Weill Medical College of Cornell University, New York Presbyterian Hospital-Westchester Division, White Plains 10605, USA.
Peptides. 1999;20(4):451-6. doi: 10.1016/s0196-9781(99)00025-x.
Food intake and meal size are reduced in female Long-Evans rats during estrus. To investigate the contribution of the satiating action of endogenous cholecystokinin (CCK) to this, rats were injected with 1 mg/kg of the potent, selective CCK(A) receptor antagonist, devazepide, during diestrus, when meal size is maximal, and during estrus, when it is minimal. Devazepide increased spontaneous food intake and meal size during estrus, but not during diestrus. Meal frequency was not affected by devazepide treatment. These results indicate that the potency of the CCK satiety-signaling system increases during estrus.
在发情期，雌性Long-Evans大鼠的食物摄入量和每餐食量会减少。为了研究内源性胆囊收缩素（CCK）的饱腹感作用对此的贡献，在间情期（此时每餐食量最大）和发情期（此时每餐食量最小）给大鼠注射1mg/kg强效、选择性CCK(A)受体拮抗剂地伐西匹。地伐西匹增加了发情期的自发食物摄入量和每餐食量，但在间情期没有这种作用。地伐西匹处理对进餐频率没有影响。这些结果表明，CCK饱腹感信号系统的效力在发情期增强。
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