Kamijo Y, Soma K, Fukuda M, Asari Y, Ohwada T
Department of Emergency and Critical Care Medicine, Kitasato University, School of Medicine, Sagamihara, Kanagawa, Japan.
J Toxicol Clin Toxicol. 1999;37(4):509-11. doi: 10.1081/clt-100102444.
An elderly Japanese woman ingested a massive quantity of phenol in a suicide attempt. She was admitted to the Emergency Department in respiratory arrest and deep coma. Duodenogastritis was evident endoscopically. With the return of spontaneous respiration and consciousness, fine, rapid rhythmic perioral movements developed together with Parkinsonian findings. The abnormal movements were aggravated by administration of a neuroleptic and ameliorated by discontinuing the drug; they disappeared completely by hospital day 15. In addition to neuroleptic drugs, phenol intoxication may cause the rabbit syndrome by inducing cholinergic dominance with relative dopamine hypofunction in the central nervous system.
一名老年日本女性为自杀企图摄入了大量苯酚。她因呼吸骤停和深度昏迷被送入急诊科。内镜检查显示十二指肠胃炎明显。随着自主呼吸和意识的恢复，出现了口周精细、快速的节律性运动以及帕金森氏症表现。使用抗精神病药物会加重异常运动，停药后则有所改善；到住院第15天时异常运动完全消失。除抗精神病药物外，苯酚中毒可能通过在中枢神经系统中诱导胆碱能占优势并伴有相对多巴胺功能减退而导致兔综合征。
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