一例与急性髓系白血病相关的inv(8)(p11q24)，在隐匿性t(8;16)中涉及MOZ和CBP基因。

A case of inv(8)(p11q24) associated with acute myeloid leukemia involves the MOZ and CBP genes in a masked t(8;16).

作者信息

Chaffanet M, Mozziconacci M J, Fernandez F, Sainty D, Lafage-Pochitaloff M, Birnbaum D, Pébusque M J

机构信息

Laboratoire d'Oncologie Moléculaire, U.119 INSERM, Marseille, France.

出版信息

Genes Chromosomes Cancer. 1999 Oct;26(2):161-5.

PMID:10469454

Abstract

We report on a novel chromosomal aberration, inv(8)(p11q24), in an M5 acute myeloid leukemia. We show by fluorescence in situ hybridization and Southern blot analyses that a t(8;16)(p11;p13) is masked by this inversion. The translocation targets the MOZ gene from the 8p11 and the CBP gene from the 16p13 chromosomal regions. The breakpoints occur in the MOZ region encoding the acidic domain and in the 5' end of the CBP gene. These results provide further evidence for the multiple contribution of both MOZ and CBP genes in acute leukemias. Genes Chromosomes Cancer 26:161-165, 1999.

摘要

我们报告了1例M5型急性髓系白血病中的一种新型染色体畸变inv(8)(p11q24)。我们通过荧光原位杂交和Southern印迹分析表明，t(8;16)(p11;p13)被这种倒位所掩盖。该易位将8p11染色体区域的MOZ基因和16p13染色体区域的CBP基因作为靶点。断点发生在编码酸性结构域的MOZ区域和CBP基因的5'端。这些结果为MOZ和CBP基因在急性白血病中的多重作用提供了进一步的证据。《基因、染色体与癌症》26:161 - 165, 1999年。