巨型蛋白酶：超越蛋白酶体

Giant proteases: beyond the proteasome.

作者信息

Yao T, Cohen R E

机构信息

Department of Biochemistry, University of Iowa, Bowen Science Building, 51 Newton Road, Iowa City, Iowa 52242-1109, USA.

出版信息

Curr Biol. 1999;9(15):R551-3. doi: 10.1016/s0960-9822(99)80352-2.

DOI:10.1016/s0960-9822(99)80352-2

PMID:10469553

Abstract

Proteasomes and related proteases are thought to be the principal machinery responsible for intracellular protein degradation. A new class of giant proteases has been discovered that can augment the catabolic functions of proteasomes and, under some conditions, may even substitute for proteasomes altogether.

摘要

蛋白酶体及相关蛋白酶被认为是负责细胞内蛋白质降解的主要机制。现已发现一类新型的巨型蛋白酶，它们能够增强蛋白酶体的分解代谢功能，并且在某些情况下甚至可能完全替代蛋白酶体。