犬疱疹病毒立即早期基因的结构
Structure of the immediate early gene of canine herpesvirus.
作者信息
Miyoshi M, Takiguchi M, Yasuda J, Hashimoto A, Takada A, Okazaki K, Kida H
机构信息
Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
出版信息
Arch Virol. 1999;144(2):407-20. doi: 10.1007/s007050050514.
The nucleotide sequence of the immediate early (IE) gene of canine herpesvirus was determined. This gene was located in the inverted repeat regions, encoding a polypeptide of 1,383 amino acids. The predicted amino acid sequence was most closely related to that of the feline herpesvirus 1 IE protein among those of other alphaherpesviruses. DNA binding and transcriptional activation domains were found in the IE protein. A spliced region of the IE gene transcript was determined in its 5' non-coding region.
测定了犬疱疹病毒即刻早期（IE）基因的核苷酸序列。该基因位于反向重复区域，编码一个由1383个氨基酸组成的多肽。在其他α疱疹病毒中，预测的氨基酸序列与猫疱疹病毒1的IE蛋白最为相似。在IE蛋白中发现了DNA结合和转录激活结构域。在IE基因转录本的5'非编码区域确定了一个剪接区域。
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