Hunt D R, Humphreys K A, Janssen J, Mackay E, Smart R
Upper Gastrointestinal Surgical Unit, St. George Hospital, Kogarah, Sydney, Australia.
J Gastrointest Surg. 1999 Sep-Oct;3(5):489-95. doi: 10.1016/s1091-255x(99)80102-4.
Fundoplication performed for gastroesophageal reflux disease may be complicated by postoperative dysphagia despite successful reduction in reflux symptoms. This is more likely in those patients with reflux who have concurrent esophageal dysmotility. The aim of this study was to establish whether esophageal transit studies using a technetium-99m jello bolus (jello esophageal transit) could detect the presence of motility disorders preoperatively and hence predict surgical outcome. Transit studies in 33 healthy volunteers yielded a normal range of 2 to 24 seconds using ninety-fifth percentile distribution. In the second phase of the study, 26 patients accepted for laparoscopic fundoplication were enrolled: jello esophageal transit, manometry, and endoscopy were attempted preoperatively in all subjects. A clinical dysphagia score was assigned from a questionnaire. Six months after surgery, five patients had dysphagia and of these four were found to have abnormal preoperative jello esophageal transit, for a sensitivity of 80%. Of the 21 patients who had no dysphagia after surgery, 20 patients had normal preoperative jello esophageal transit, showing a specificity of 95%. This esophageal transit study is noninvasive, reliable, and sensitive. When performed prior to fundoplication, it appears to be of significant value in detecting a subtle functional motility disorder that predisposes to postoperative dysphagia. Jello esophageal transit may assist the surgeon in planning treatment of gastroesophageal reflux disease.
尽管胃食管反流病患者在进行胃底折叠术后反流症状成功减轻,但仍可能并发术后吞咽困难。对于同时存在食管动力障碍的反流患者,这种情况更为常见。本研究的目的是确定使用锝-99m果胶团块进行的食管通过时间研究(果胶食管通过时间)能否在术前检测到动力障碍的存在,从而预测手术结果。33名健康志愿者的通过时间研究使用第95百分位数分布得出正常范围为2至24秒。在研究的第二阶段,纳入了26名接受腹腔镜胃底折叠术的患者:所有受试者术前均尝试进行果胶食管通过时间、测压和内镜检查。通过问卷调查得出临床吞咽困难评分。术后6个月,5名患者出现吞咽困难,其中4名患者术前果胶食管通过时间异常,敏感性为80%。在术后无吞咽困难的21名患者中,20名患者术前果胶食管通过时间正常,特异性为95%。这项食管通过时间研究具有非侵入性、可靠性和敏感性。在胃底折叠术前进行时,它似乎在检测导致术后吞咽困难的细微功能性动力障碍方面具有重要价值。果胶食管通过时间可能有助于外科医生规划胃食管反流病的治疗。