海星卵母细胞减数分裂重新启动时MPF的激活。

Activation of MPF at meiosis reinitiation in starfish oocytes.

作者信息

Kishimoto T

机构信息

Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Nagatsuta 4259, Yokohama, Midoriku, 226-8501, Japan.

出版信息

Dev Biol. 1999 Oct 1;214(1):1-8. doi: 10.1006/dbio.1999.9393.

DOI:10.1006/dbio.1999.9393

PMID:10491252

Abstract

Although maturation or M-phase-promoting factor (MPF) was originally identified as a cytoplasmic activity responsible for induction of maturation or meiosis reinitiation in oocytes, MPF is now thought to be the universal trigger of G2/M-phase transition in all eukaryotic cells, and its activity is ascribed to cyclin B. Cdc2 kinase. Here, the activation process of cyclin B. Cdc2 at meiosis reinitiation in starfish oocytes is compared with that at G2/M-phase transition in mitotic somatic cells. Based on this comparison, the role of cyclin B. Cdc2 in the original cytoplasmic MPF activity is reexamined.

摘要

尽管成熟促进因子（MPF）最初被鉴定为一种细胞质活性物质，负责诱导卵母细胞成熟或减数分裂重新启动，但现在认为MPF是所有真核细胞中G2/M期转换的通用触发因子，其活性归因于细胞周期蛋白B·Cdc2激酶。在此，将海星卵母细胞减数分裂重新启动时细胞周期蛋白B·Cdc2的激活过程与有丝分裂体细胞中G2/M期转换时的激活过程进行比较。基于这种比较，重新审视细胞周期蛋白B·Cdc2在原始细胞质MPF活性中的作用。