硫酸化糊精的抗卡波西肉瘤及抗血管生成活性
Anti-Kaposi's sarcoma and antiangiogenic activities of sulfated dextrins.
作者信息
Thornton M, Barkley L, Mason J C, Shaunak S
机构信息
Departments of Infectious Diseases, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom.
出版信息
Antimicrob Agents Chemother. 1999 Oct;43(10):2528-33. doi: 10.1128/AAC.43.10.2528.
Delivery of the sulfated polysaccharide dextrin 2-sulfate by the intraperitoneal route to the lymphatic circulation resulted in a clinically significant improvement in Kaposi's sarcoma in three patients. Our in vitro studies show that although sulfated dextrins do not interfere with the growth of isolated human umbilical vein endothelial cells, they do inhibit the morphological differentiation of endothelial cells into tubes as well as reduce new vessel formation in a placental angiogenesis assay. The antiangiogenic effect of dextrin 6-sulfate is greater than that of dextrin 2-sulfate and is independent of their anti-human immunodeficiency virus type 1 activities.
通过腹腔途径将硫酸化多糖糊精2-硫酸盐递送至淋巴循环，使三名卡波西肉瘤患者的病情得到了临床上显著的改善。我们的体外研究表明，虽然硫酸化糊精不干扰分离的人脐静脉内皮细胞的生长，但它们确实会抑制内皮细胞向管状结构的形态分化，并减少胎盘血管生成试验中的新血管形成。硫酸糊精6-硫酸盐的抗血管生成作用大于硫酸糊精2-硫酸盐，且与它们的抗1型人类免疫缺陷病毒活性无关。
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