利用血红素模型增强青蒿素对氯喹耐药恶性疟原虫菌株的活性。
Potentiation of artemisinin activity against chloroquine-resistant Plasmodium falciparum strains by using heme models.
作者信息
Benoit-Vical F, Robert A, Meunier B
机构信息
Laboratoire d'Immunologie et Parasitologie, UFR Sciences Pharmaceutiques, 34060 Montpellier Cedex 2, France.
出版信息
Antimicrob Agents Chemother. 1999 Oct;43(10):2555-8. doi: 10.1128/AAC.43.10.2555.
Abstract
The influence of different metalloporphyrin derivatives on the antimalarial activity of artemisinin was studied with two chloroquine-resistant strains of Plasmodium falciparum (FcB1-Colombia and FcM29-Cameroon) cultured in human erythrocytes. This potentiation study indicates that the manganese complex of meso-tetrakis(4-sulfonatophenyl)porphyrin has a significant synergistic effect on the activity of artemisinin against both Plasmodium strains.
摘要
在人红细胞中培养的两株氯喹耐药恶性疟原虫（FcB1-哥伦比亚株和FcM29-喀麦隆株）上，研究了不同金属卟啉衍生物对青蒿素抗疟活性的影响。这项增效研究表明，中-四（4-磺酸苯基）卟啉锰配合物对青蒿素针对这两种疟原虫株的活性具有显著的协同作用。
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