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[促活素和左旋咪唑对中毒性脑水肿肿胀发展的影响]

[The effect of tactivin and levamisole on the development of toxic brain edema-swelling].

作者信息

Platonov I A, Andreeva T A

机构信息

Smolensk State Medical Academy, Russia.

出版信息

Eksp Klin Farmakol. 1999 Jul-Aug;62(4):62-4.

Abstract

Edema-swelling of the brain (ESB) is among the urgent problems of modern medicine. The purpose of the research was the study of the effect of immunotropic agents on formation of the pathologic process. It was demonstrated on a model of toxic ESB that taktivin and levamisole possess antiedemic activity. The effect is dose-dependent and is determined by the structural characteristics of the drugs under study. Unlike taktivin, large doses of levamisole demonstrate synergism with the effect of the edematous factor.

摘要

脑水肿是现代医学的紧迫问题之一。本研究的目的是探讨免疫调节药物对病理过程形成的影响。在中毒性脑水肿模型上证实,泰洛菌素和左旋咪唑具有抗水肿活性。这种作用呈剂量依赖性,由所研究药物的结构特征决定。与泰洛菌素不同,大剂量的左旋咪唑与水肿因子的作用表现出协同作用。

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