Feldman C
Department of Medicine, University of Witwatersrand, Johannesburg, South Africa.
Clin Chest Med. 1999 Sep;20(3):563-73. doi: 10.1016/s0272-5231(05)70236-7.
Pneumonia, including community-acquired, long-term care facility-associated, and nosocomial infections, is a major cause of morbidity and mortality in the elderly. The aged with pneumonia often present with atypical features, including confusion, lethargy, and general deterioration of condition (so-called "silent infection"). Further investigations, such as a chest radiograph, are more frequently required for diagnosis, but even these results may be normal early in the course of infection, particularly in dehydrated patients. The elderly are more frequently hospitalized for pneumonia and have a greater need for intravenous therapy, longer hospital stay, more prolonged course, greater morbidity, and, ultimately, a poorer outcome. Yet in many studies it is not chronological age per se that impacts negatively on the manifestations of pneumonia in the elderly but rather the presence of comorbid illness. Antibiotic therapy remains the mainstay of therapy for pneumonia, and both community and hospital-based studies confirm the important positive impact of early appropriate empiric antibiotic therapy on outcome. Attention to nutrition and hydration, the use of pneumococcal and influenza vaccination, and a number of diverse procedures in the hospital setting may help limit the occurrence and impact of such infections.
肺炎,包括社区获得性肺炎、长期护理机构相关性肺炎和医院获得性感染,是老年人发病和死亡的主要原因。患肺炎的老年人常表现出非典型症状,包括意识模糊、嗜睡和病情总体恶化(即所谓的“隐性感染”)。诊断通常需要进一步检查,如胸部X光片,但即使这些检查结果在感染早期也可能正常,尤其是在脱水患者中。老年人因肺炎住院的频率更高,更需要静脉治疗,住院时间更长,病程更长,发病率更高,最终预后更差。然而,在许多研究中,对老年人肺炎表现产生负面影响的并非实际年龄本身,而是合并症的存在。抗生素治疗仍然是肺炎治疗的主要手段,社区和医院研究均证实早期适当的经验性抗生素治疗对预后有重要的积极影响。关注营养和水合作用、使用肺炎球菌和流感疫苗以及医院环境中的一些不同程序可能有助于限制此类感染的发生和影响。