母血清和脐带血中的瘦素浓度：与母亲人体测量学和胎儿生长的关系。

Leptin concentrations in maternal serum and cord blood: relationship to maternal anthropometry and fetal growth.

作者信息

Geary M, Pringle P J, Persaud M, Wilshin J, Hindmarsh P C, Rodeck C H, Brook C G

机构信息

Department of Obstetrics and Gynaecology, University College London.

出版信息

Br J Obstet Gynaecol. 1999 Oct;106(10):1054-60. doi: 10.1111/j.1471-0528.1999.tb08113.x.

DOI:10.1111/j.1471-0528.1999.tb08113.x

PMID:10519431

Abstract

OBJECTIVE

To determine 1. the relationship between maternal serum leptin concentrations and maternal anthropometry and 2. the relationship between cord serum leptin concentrations at birth and neonatal anthropometry.

DESIGN

Prospective cohort study of fetal growth in low-risk pregnancies.

SETTING

University teaching hospital.

SAMPLE

Thirty-nine women and their babies taking part in a fetal growth study.

METHODS

Blood was taken from the women between 10-20 weeks of gestation and from the umbilical cord of their babies at delivery. Serum leptin was measured by radio-immunoassay. Maternal anthropometric measurements were recorded at booking. Neonatal anthropometric measurements were recorded within 48 hours after delivery. Linear regression analysis was used to explore the relationship between serum leptin concentrations and anthropometric measures and multiple regression analysis then applied to determine which variables remained independently associated with leptin.

RESULTS

The median (range) leptin concentration in maternal serum was 11.8 ng/mL (1.7-39.7) and in cord blood was 4.2 ng/mL (0.6-21.4). Maternal leptin levels correlated with maternal weight, body mass index, midarm circumference and skinfold thickness, but not with birthweight, placental weight or maternal height. Body mass index and midarm circumference remained significant after multiple regression analysis. Cord leptin levels correlated with birthweight, birthlength, placental weight and skinfold thickness but not with ponderal index. Birthweight and subscapular skinfold thickness remained significant after multiple regression analysis. Cord leptin concentrations did not correlate with maternal leptin concentrations.

CONCLUSIONS

We suggest that there are very strong associations between maternal leptin and maternal adiposity in pregnancy, and between cord leptin at delivery and birthweight, as well as other anthropometric markers of fetal growth.

摘要

目的

确定母体血清瘦素浓度与母体人体测量指标之间的关系；2. 确定出生时脐血瘦素浓度与新生儿人体测量指标之间的关系。

设计

对低风险妊娠胎儿生长情况的前瞻性队列研究。

地点

大学教学医院。

样本

39名参与胎儿生长研究的妇女及其婴儿。

方法

在妊娠10至20周期间采集孕妇血液，并在分娩时采集其婴儿的脐带血。采用放射免疫分析法测定血清瘦素。在预约时记录孕妇人体测量指标。在分娩后48小时内记录新生儿人体测量指标。采用线性回归分析探讨血清瘦素浓度与人体测量指标之间的关系，然后应用多元回归分析确定哪些变量与瘦素保持独立相关。

结果

母体血清中瘦素浓度的中位数（范围）为11.8 ng/mL（1.7 - 39.7），脐血中为4.2 ng/mL（0.6 - 21.4）。母体瘦素水平与母体体重、体重指数、上臂围和皮褶厚度相关，但与出生体重、胎盘重量或母体身高无关。多元回归分析后，体重指数和上臂围仍具有显著性。脐血瘦素水平与出生体重、出生身长、胎盘重量和皮褶厚度相关，但与 ponderal 指数无关。多元回归分析后，出生体重和肩胛下皮褶厚度仍具有显著性。脐血瘦素浓度与母体瘦素浓度不相关。