Semisynthesis and cytotoxicity of amino acetogenins and derivatives.
作者信息
Duret P, Hocquemiller R, Gantier J C, Figadère B
机构信息
Laboratoire de Pharmacognosie associéau CNRS (BIOCIS), Facultéde Pharmacie, Université Paris-Sud, Châtenay-Malabry, France.
出版信息
Bioorg Med Chem. 1999 Sep;7(9):1821-6. doi: 10.1016/s0968-0896(99)00135-2.
Abstract
Semisynthetic derivatives were prepared from two natural annonaceous acetogenins, rolliniastatin-1 and squamocin, and their cytotoxicity was evaluated. Amino derivatives show decreased bioactivity. Isorolliniastatin-1 was found to be much less toxic than rolliniastatin-1 after intraperitoneal administration to mice, although the in vitro cytotoxicity of both compounds was comparable.
摘要
Zotero 插件