Watanuki N, Takahashi A, Yasuda A, Sakai M
Faculty of Agriculture, Miyazaki University, Japan.
Vet Immunol Immunopathol. 1999 Oct 18;71(2):89-97. doi: 10.1016/s0165-2427(99)00089-6.
The immunomodulatory effects of beta-endorphin were studied by measurements of the production of superoxide anion, phagocytosis and chemotaxis of kidney phagocytic cells in rainbow trout, Oncorhynchus mykiss. The production of superoxide anion in phagocytic cells increased significantly in rainbow trout injected with chum salmon beta-endorphin. The responses were dose-dependent. The phagocytosis and chemotaxis also significantly increased in kidney phagocytic cells of rainbow trout injected with alpha-endorphin. These results show that beta-endorphin in rainbow trout activates the function of phagocytic cells in vivo.
通过测量虹鳟(Oncorhynchus mykiss)肾吞噬细胞中超氧阴离子的产生、吞噬作用和趋化性,研究了β-内啡肽的免疫调节作用。注射了大麻哈鱼β-内啡肽的虹鳟吞噬细胞中超氧阴离子的产生显著增加。这些反应呈剂量依赖性。注射α-内啡肽的虹鳟肾吞噬细胞的吞噬作用和趋化性也显著增加。这些结果表明,虹鳟体内的β-内啡肽可激活吞噬细胞的功能。