测量弱视中的颜色竞争抑制。

Measuring colour rivalry suppression in amblyopia.

作者信息

Hofeldt T S, Hofeldt A J

机构信息

Edward S Harkness Eye Institute, Columbia University, New York 10021, USA.

出版信息

Br J Ophthalmol. 1999 Nov;83(11):1283-6. doi: 10.1136/bjo.83.11.1283.

DOI:10.1136/bjo.83.11.1283

PMID:10535858

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1722877/

Abstract

AIMS

To determine if the colour rivalry suppression is an index of the visual impairment in amblyopia and if the stereopsis and fusion evaluator (SAFE) instrument is a reliable indicator of the difference in visual input from the two eyes.

METHODS

To test the accuracy of the SAFE instrument for measuring the visual input from the two eyes, colour rivalry suppression was measured in six normal subjects. A test neutral density filter (NDF) was placed before one eye to induce a temporary relative afferent defect and the subject selected the NDF before the fellow eye to neutralise the test NDF. In a non-paediatric private practice, 24 consecutive patients diagnosed with unilateral amblyopia were tested with the SAFE. Of the 24 amblyopes, 14 qualified for the study because they were able to fuse images and had no comorbid disease. The relation between depth of colour rivalry suppression, stereoacuity, and interocular difference in logMAR acuity was analysed.

RESULTS

In normal subjects, the SAFE instrument reversed temporary defects of 0.3 to 1. 8 log units to within 0.6 log units. In amblyopes, the NDF to reverse colour rivalry suppression was positively related to interocular difference in logMAR acuity (beta=1.21, p<0.0001), and negatively related to stereoacuity (beta=-0.16, p=0.019). The interocular difference in logMAR acuity was negatively related to stereoacuity (beta=-0.13, p=0.009).

CONCLUSIONS

Colour rivalry suppression as measured with the SAFE was found to agree closely with the degree of visual acuity impairment in non-paediatric patients with amblyopia.

摘要

目的

确定颜色竞争抑制是否为弱视视力损害的指标，以及立体视和融合评估器（SAFE）仪器是否是双眼视觉输入差异的可靠指标。

方法

为测试SAFE仪器测量双眼视觉输入的准确性，对6名正常受试者进行颜色竞争抑制测量。在一只眼前放置测试中性密度滤光片（NDF）以诱发暂时的相对性传入缺陷，受试者在对侧眼前选择NDF以中和测试NDF。在一家非儿科私人诊所，对24例连续诊断为单侧弱视的患者使用SAFE进行测试。在这24例弱视患者中，14例符合研究条件，因为他们能够融合图像且无合并疾病。分析了颜色竞争抑制深度、立体视锐度和对数最小分辨角（logMAR）视力的双眼差异之间的关系。

结果

在正常受试者中，SAFE仪器将0.3至1.8对数单位的暂时缺陷纠正至0.6对数单位以内。在弱视患者中，逆转颜色竞争抑制的NDF与logMAR视力的双眼差异呈正相关（β=1.21，p<0.0001），与立体视锐度呈负相关（β=-0.16，p=0.019）。logMAR视力的双眼差异与立体视锐度呈负相关（β=-0.13，p=0.009）。