Budde W M, Jonas J B
Augenklinik mit Poliklinik der Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen.
Klin Monbl Augenheilkd. 1999 Oct;215(4):211-20. doi: 10.1055/s-2008-1034702.
Previous studies have shown that the chronic open-angle glaucomas form a heterogeneous spectrum of diseases which have in common an open anterior chamber angle and glaucomatous optic nerve damage. Purpose of this study was to evaluate whether the appearance of the optic disc differs among the various types of primary open-angle glaucoma.
Color stereo optic disc photographs of 683 patients with primary open-angle glaucoma (POAG), and 481 normal eyes were morphometrically evaluated.
Morphologic characteristics of the glaucoma types were as follows: Highly myopic POAG: secondary macrodiscs with abnormal shape; shallow, flat, concentric disc cupping; low frequency of disc hemorrhages; large parapapillary atrophy or myopic crescent; medium to low intraocular pressure. Juvenile-onset POAG: Optic disc of normal size and shape; deep and steep disc cupping; low frequency of broad rim notches or large disc hemorrhages; small parapapillary atrophy; high minimal and maximal intraocular pressure measurements. Age-related atrophic POAG: Optic disc of normal size and shape; shallow, flat and concentric disc cupping; medium to low frequency of disc hemorrhages; large parapapillary atrophy; medium to low intraocular pressure. Eyes with normal-pressure glaucoma: Optic disc of normal size and shape; deep and steep cupping; relatively small parapapillary atrophy; high frequency of disc hemorrhages and rim notches.
These characteristics in the appearance of the optic disc may be helpful for clinical diagnosis and therapy and may give pathogenetic hints.
既往研究表明,慢性开角型青光眼构成了一组异质性疾病谱,其共同特征为前房角开放和青光眼性视神经损害。本研究的目的是评估不同类型的原发性开角型青光眼视盘外观是否存在差异。
对683例原发性开角型青光眼(POAG)患者和481例正常眼的彩色立体视盘照片进行形态计量学评估。
各型青光眼的形态学特征如下:高度近视性POAG:继发性大视盘,形态异常;盘沿凹陷浅、平、呈同心圆状;视盘出血频率低;视盘旁萎缩大或有近视性弧形斑;眼压中至低。青少年型POAG:视盘大小和形态正常;盘沿凹陷深且陡;宽边切迹或大视盘出血频率低;视盘旁萎缩小;眼压测量的最小值和最大值高。年龄相关性萎缩性POAG:视盘大小和形态正常;盘沿凹陷浅、平、呈同心圆状;视盘出血频率中至低;视盘旁萎缩大;眼压中至低。正常眼压性青光眼:视盘大小和形态正常;盘沿凹陷深且陡;视盘旁萎缩相对小;视盘出血和切迹频率高。
视盘外观的这些特征可能有助于临床诊断和治疗,并可能提供发病机制方面的线索。