用枝状外瓶霉变种角状变种和奇异长喙壳菌进行的类固醇转化。

Steroid transformations with Exophiala jeanselmei var. lecanii-corni and Ceratocystis paradoxa.

作者信息

Porter R B, Gallimore W A, Reese P B

机构信息

Chemistry Department, University of the West Indies, Mona, Kingston, Jamaica.

出版信息

Steroids. 1999 Nov;64(11):770-9. doi: 10.1016/s0039-128x(99)00066-5.

DOI:10.1016/s0039-128x(99)00066-5

PMID:10577834

Abstract

The fungi Exophiala jeanselmei var. lecanii-corni [IMI (International Mycological Institute) 312989, UAMH (University of Alberta Microfungus Collection and Herbarium) 8783] and Ceratocystis paradoxa (IMI 374529, UAMH 8784) have been examined for their potential in steroid biotransformation. The study has determined that E. jeanselmei var. lecanii-corni effected overall anti-Markovnikov hydration on dehydroisoandrosterone, and side-chain degradation on a variety of pregnanes. Both ascomycetes were found to carry out redox reactions of alcohols and ketones as well as 1,4 reduction of alpha,beta-unsaturated carbonyl systems.

摘要

已对真菌耶氏外瓶霉勒氏变种[国际真菌学研究所（IMI）312989，阿尔伯塔大学真菌菌种保藏中心（UAMH）8783]和奇异长喙壳菌（IMI 374529，UAMH 8784）在甾体生物转化方面的潜力进行了研究。该研究已确定，耶氏外瓶霉勒氏变种对脱氢异雄酮进行了总体反马氏水合反应，并对多种孕烷进行了侧链降解。发现这两种子囊菌都能进行醇和酮的氧化还原反应以及α,β-不饱和羰基体系的1,4还原反应。