Murgia R, Marchetti F, Cinco M
Department of Biomedical Science, University of Trieste, 34127 Trieste, Italy.
Antimicrob Agents Chemother. 1999 Dec;43(12):3030-2. doi: 10.1128/AAC.43.12.3030.
The MIC and MSC (minimum spirocheticidal concentration) and killing rate for Borrelia burgdorferi, the etiological agent of Lyme disease, were assessed for cefodizime in comparison with ceftriaxone, minocycline, azithromycin, roxithromycin, and ciprofloxacin. The range of cefodizime MICs was greater than those of azithromycin and roxithromycin but comparable to those of ceftriaxone and minocycline. The MSCs were 1 to 2 dilutions higher than the MICs of all of the tested compounds. The killing curves of cefodizime and ceftriaxone showed parallel courses. In conclusion, cefodizime exerted an activity comparable to that of ceftriaxone against B. burgdorferi.
对头孢地嗪与头孢曲松、米诺环素、阿奇霉素、罗红霉素和环丙沙星相比,评估其对莱姆病病原体伯氏疏螺旋体的最低抑菌浓度(MIC)、最低杀螺旋体浓度(MSC)和杀灭率。头孢地嗪的MIC范围大于阿奇霉素和罗红霉素,但与头孢曲松和米诺环素相当。MSC比所有测试化合物的MIC高1至2个稀释度。头孢地嗪和头孢曲松的杀灭曲线显示出平行过程。总之,头孢地嗪对伯氏疏螺旋体的活性与头孢曲松相当。