Nordbo H
Pharmacol Ther Dent. 1975;2(2):133-8.
The aim of the present investigation was to estimate the local effect of three plaque-inhibiting drugs on some glycosaminoglycans in rat skin. The drugs comprised chlorhexidine, dichlorhexidine, and trichlorhexidine; and the glycosaminoglycans examined were hyaluronic acid, chondroitin sulfate, and heparin. Glycosaminoglycans were measured by the carbazole method. Upon subcutaneous injections in rats, chlorhexidine, dichlorhexidine, and trichlorhexidine caused marked reductions in the surrounding skin's content of total hexosamine as well as of the three types of glycosaminoglycans. No significant difference could be demonstrated between the different types of glycosaminoglycans in this respect.
本研究的目的是评估三种菌斑抑制药物对大鼠皮肤中某些糖胺聚糖的局部作用。这些药物包括氯己定、双氯己定和三氯己定；所检测的糖胺聚糖为透明质酸、硫酸软骨素和肝素。糖胺聚糖采用咔唑法测定。在大鼠皮下注射后，氯己定、双氯己定和三氯己定导致周围皮肤中总己糖胺以及三种糖胺聚糖的含量显著降低。在这方面，不同类型的糖胺聚糖之间未显示出显著差异。
