Tbx5与视网膜顶盖投射

Tbx5 and the retinotectum projection.

作者信息

Koshiba-Takeuchi K, Takeuchi J K, Matsumoto K, Momose T, Uno K, Hoepker V, Ogura K, Takahashi N, Nakamura H, Yasuda K, Ogura T

机构信息

Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5, Takayama, Ikoma, Nara, Japan 630-0101.

出版信息

Science. 2000 Jan 7;287(5450):134-7. doi: 10.1126/science.287.5450.134.

DOI:10.1126/science.287.5450.134

PMID:10615048

Abstract

Dorsal and ventral aspects of the eye are distinct from the early stages of development. The developing eye cup grows dorsally, and the choroidal fissure is formed on its ventral side. Retinal axons from the dorsal and ventral retina project to the ventral and dorsal tectum, respectively. Misexpression of the Tbx5 gene induced dorsalization of the ventral side of the eye and altered projections of retinal ganglion cell axons. Thus, Tbx5 is involved in eye morphogenesis and is a topographic determinant of the visual projections between retina and tectum.

摘要

眼睛的背侧和腹侧在发育早期就有所不同。发育中的眼杯向背侧生长，脉络膜裂在其腹侧形成。来自背侧和腹侧视网膜的视网膜轴突分别投射到腹侧和背侧顶盖。Tbx5基因的错误表达诱导了眼睛腹侧的背侧化，并改变了视网膜神经节细胞轴突的投射。因此，Tbx5参与眼睛形态发生，是视网膜与顶盖之间视觉投射的拓扑决定因素。