孕10至14周时静脉导管血流异常的染色体正常胎儿的心脏缺陷
Cardiac defects in chromosomally normal fetuses with abnormal ductus venosus blood flow at 10-14 weeks.
作者信息
Matias A, Huggon I, Areias J C, Montenegro N, Nicolaides K H
机构信息
Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, London, UK.
出版信息
Ultrasound Obstet Gynecol. 1999 Nov;14(5):307-10. doi: 10.1046/j.1469-0705.1999.14050307.x.
OBJECTIVE
To assess a possible relationship between ductus venosus blood flow abnormalities and cardiac defects in chromosomally normal fetuses with increased nuchal translucency thickness at 10-14 weeks of gestation.
METHODS
Ductus venosus Doppler ultrasound blood flow velocity waveforms were obtained at 10-14 weeks' gestation immediately before fetal karyotyping in 200 consecutive singleton pregnancies with increased nuchal translucency. Fetal echocardiography was subsequently carried out in those with normal fetal karyotype.
RESULTS
Reverse or absent flow during atrial contraction was observed in 11 of the 142 chromosomally normal fetuses with increased nuchal translucency. Major defects of the heart and/or great arteries were present in seven of the 11 with abnormal ductal flow and increased nuchal translucency, but in none of the 131 with normal flow.
CONCLUSION
These preliminary results suggest that abnormal ductus venosus blood flow in chromosomally normal fetuses with increased nuchal translucency identifies those with an underlying major cardiac defect.
目的
评估妊娠10 - 14周时颈部半透明厚度增加的染色体正常胎儿的静脉导管血流异常与心脏缺陷之间的可能关系。
方法
对200例连续的颈部半透明厚度增加的单胎妊娠进行研究，在妊娠10 - 14周进行胎儿核型分析前，获取静脉导管多普勒超声血流速度波形。随后对胎儿核型正常的孕妇进行胎儿超声心动图检查。
结果
在142例颈部半透明厚度增加的染色体正常胎儿中，有11例在心房收缩期出现反向或无血流信号。导管血流异常且颈部半透明厚度增加的11例胎儿中，有7例存在心脏和/或大动脉的主要缺陷，而131例血流正常的胎儿中无一例出现此类情况。
结论
这些初步结果表明，颈部半透明厚度增加的染色体正常胎儿的静脉导管血流异常可识别出存在潜在主要心脏缺陷的胎儿。
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