Neuman S M, Kenney E B, Traurig H
J Periodontol. 1976 Mar;47(3):171-9. doi: 10.1902/jop.1976.47.3.171.
Dextrans derived from Leuconostoc mesenteroides were placed on clinically healthy gingiva of Beagle dogs once a day for 21 days. Control gingival tissues received saline. Both healthy controls and dextran-treated tissues were brushed daily. Inflamed control tissues were obtained by allowing plaque to accumulate for 21 days. Tissues receiving daily application of dextran solutions developed chronic gingival inflammation but displayed no clinical signs of gingivitis. Healthy control gingival tissues showed no clinical signs of gingivitis and minor histologic inflammatory changes. Tissues exposed to dental plaque showed the typical clinical and histological inflammatory changes of gingivitis. Thus dextran, a substance similar to the extracellular polysaccharide found in dental plaque, was able to penetrate the sulcular epithelium, enter healthy gingival connective tissue and cause chronic inflammation. This connective tissue inflammation occurred without inducing any of the clinical signs of gingivitis. Therefore, it is concluded that dextran produced one component of the gingivitis response, chronic histologic inflammation, independent of another major component of the disease, clinical inflammation.
将源自肠系膜明串珠菌的葡聚糖每天一次放置在比格犬临床健康的牙龈上，持续21天。对照牙龈组织用生理盐水处理。健康对照组织和经葡聚糖处理的组织每天都进行刷牙。通过让牙菌斑积聚21天获得炎症对照组织。每天应用葡聚糖溶液处理的组织出现了慢性牙龈炎症，但未表现出牙龈炎的临床症状。健康对照牙龈组织未表现出牙龈炎的临床症状，组织学上有轻微的炎症变化。暴露于牙菌斑的组织表现出典型的牙龈炎临床和组织学炎症变化。因此，葡聚糖这种与牙菌斑中发现的细胞外多糖相似的物质，能够穿透龈沟上皮，进入健康的牙龈结缔组织并引起慢性炎症。这种结缔组织炎症在不诱发任何牙龈炎临床症状的情况下发生。因此，可以得出结论，葡聚糖产生了牙龈炎反应的一个组成部分，即慢性组织学炎症，而与该疾病的另一个主要组成部分临床炎症无关。
Zotero 插件