小磷酸化染色质肽与DNA的结合。
Binding of small phosphorylated chromatin peptides to DNA.
作者信息
Cardellini E, Adami F, Gianfranceschi G L
机构信息
Dipartimento di Biologia Cellulare e Molecolare, Sez. di Fisiologia e Biofisica, Università di Perugia, Italy.
出版信息
Mol Biol Rep. 1999 Dec;26(4):249-53. doi: 10.1023/a:1007073426859.
PMID:10634507
Abstract
Low-molecular-weight peptides involved in gene expression and cell growth have been isolated from DNA preparation from eukaryotic cells. After phosphorylation with protein kinase CKII (pCKII) these peptides are able to bind to DNA in presence of divalent cations and salt/ethanol. This finding may explain the mechanism by which the peptides exert their activity.
摘要
从真核细胞的DNA制备物中分离出了参与基因表达和细胞生长的低分子量肽。在用蛋白激酶CKII（pCKII）磷酸化后，这些肽在二价阳离子和盐/乙醇存在的情况下能够与DNA结合。这一发现可能解释了这些肽发挥其活性的机制。
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