两性霉素B衍生物MS - 8209对巨噬细胞中肿瘤坏死因子α合成及人类免疫缺陷病毒复制的影响。
Effects of MS-8209, an amphotericin B derivative, on tumor necrosis factor alpha synthesis and human immunodeficiency virus replication in macrophages.
作者信息
Clayette P, Martin M, Beringue V, Dereuddre-Bosquet N, Adjou K T, Seman M, Dormont D
机构信息
CEA, Service de Neurovirologie, DSV/DRM, CRSSA, IPSC, Fontenay aux Roses, Paris, France.
出版信息
Antimicrob Agents Chemother. 2000 Feb;44(2):405-7. doi: 10.1128/AAC.44.2.405-407.2000.
Abstract
Amphotericin B derivatives, such as MS-8209, have been evaluated as a therapeutic approach to human immunodeficiency virus (HIV) infection. We show that MS-8209, like amphotericin B, increases tumor necrosis factor alpha (TNF-alpha) mRNA expression and TNF-alpha production and consequently HIV replication in human macrophages. These effects confirm the pharmacological risk associated with the administration of amphotericin B or its derivatives to HIV-infected patients.
摘要
两性霉素B衍生物，如MS-8209，已被评估作为一种治疗人类免疫缺陷病毒（HIV）感染的方法。我们发现，MS-8209与两性霉素B一样，会增加肿瘤坏死因子α（TNF-α）的mRNA表达和TNF-α的产生，进而导致人类巨噬细胞中的HIV复制。这些效应证实了向HIV感染患者施用两性霉素B或其衍生物存在的药理学风险。
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