[昂丹司琼对大鼠的抗焦虑作用及其消除苯二氮䓬戒断综合征的能力]

[The anxiolytic effect of ondansetron and its capacity to eliminate the benzodiazepine abstinence syndrome in rats].

作者信息

Garibova T L, Voronina T A, Kraĭneva V A, Val'dman E A

机构信息

Laboratory of Psychopharmacology, Institute of Pharmacology, Moscow, Russia.

出版信息

Eksp Klin Farmakol. 1999 Nov-Dec;62(6):16-9.

PMID:10650519

Abstract

Ondansetron (GR38032F, zofran)--a specific blocker of 5-HT3-receptors in a dose range of 0.05 to 0. mg/kg causes an anxiolytic effect in experiments on mice and rats on a model of elevated plus maze. The drug does not produce a sedative and myorelaxant effect. A 0.05 mg/kg dose of ondansetron reduces the level of anxiety and convulsive manifestations which are induced by discontinuation of long-term diazepam administration. The results of the study bear evidence of selectivity of the anxiolytic effect of ondansetron in intact animals and its effectiveness in rats with diazepam abstinence.

摘要

昂丹司琼（GR38032F，佐芬）——一种5-HT3受体特异性阻滞剂，在0.05至0.毫克/千克的剂量范围内，在高架十字迷宫模型的小鼠和大鼠实验中产生抗焦虑作用。该药物不会产生镇静和肌松作用。0.05毫克/千克剂量的昂丹司琼可降低因长期停用地西泮而诱发的焦虑水平和惊厥表现。研究结果证明了昂丹司琼在完整动物中抗焦虑作用的选择性及其在有地西泮戒断的大鼠中的有效性。