化学致癌性：能否从致突变性和过敏性接触性皮炎的相关知识中预测出来？

Chemical carcinogenicity: can it be predicted from knowledge of mutagenicity and allergic contact dermatitis?

作者信息

Rosenkranz H S, Karol M H

机构信息

Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA.

出版信息

Mutat Res. 1999 Dec 16;431(1):81-91. doi: 10.1016/s0027-5107(99)00168-2.

DOI:10.1016/s0027-5107(99)00168-2

PMID:10656488

Abstract

We investigated the suggestion [R.E. Albert, Environ. Health Perspect. 105 (1997) 940-948.] that results of mutagenicity testing in Salmonella combined with allergic contact dermatitis (ACD) testing in humans would be predictive of carcinogenicity in rodents. Using the cancer bioassay results of the US National Toxicology Program (NTP), Salmonella mutagenicity tests and a highly predictive structure-activity relational model of ACD, we conclude that the combination is not more predictive than the results of the Salmonella mutagenicity assay alone.

摘要

我们研究了这样一种观点[R.E. 阿尔伯特，《环境健康展望》105 (1997) 940 - 948]，即沙门氏菌致突变性测试结果与人体过敏性接触性皮炎（ACD）测试结果相结合可预测啮齿动物的致癌性。利用美国国家毒理学计划（NTP）的癌症生物测定结果、沙门氏菌致突变性测试以及一个对ACD具有高度预测性的构效关系模型，我们得出结论，这种组合并不比单独的沙门氏菌致突变性测定结果更具预测性。