精神分裂症中遗传因素对偏侧性的影响？一项关于神经学软体征的双生子研究。
Genetic influence on laterality in schizophrenia? A twin study of neurological soft signs.
作者信息
Niethammer R, Weisbrod M, Schiesser S, Grothe J, Maier S, Peter U, Kaufmann C, Schröder J, Sauer H
机构信息
Department of Psychiatry, University of Heidelberg, Germany.
出版信息
Am J Psychiatry. 2000 Feb;157(2):272-4. doi: 10.1176/appi.ajp.157.2.272.
OBJECTIVE
This study explored the genetic basis of neurological soft signs in schizophrenia and addressed disturbed hemispheric lateralization.
METHOD
The authors investigated neurological soft signs in 30 monozygotic twin pairs, 13 pairs discordant for schizophrenia or schizoaffective disorder and 17 healthy comparison twin pairs.
RESULTS
The twins with schizophrenia showed higher total scores for neurological soft signs than did the comparison subjects. The total scores for neurological soft signs of the nonaffected discordant twins were significantly higher than those of the comparison twins. There was a significant difference between the nonaffected and affected discordant twins in total scores for neurological soft signs. In contrast to the comparison subjects, the nonaffected and affected twins of the discordant pairs showed a trend toward higher scores for neurological soft signs on the left body half.
CONCLUSIONS
These results suggest that the occurrence of neurological soft signs and, more specifically, their lateralization to the left body half are genetically transmitted.
目的
本研究探讨了精神分裂症神经软体征的遗传基础，并探讨了半球偏侧化异常。
方法
作者对30对同卵双胞胎进行了神经软体征调查，其中13对双胞胎中一方患有精神分裂症或分裂情感性障碍，另一方健康，作为对照。
结果
患有精神分裂症的双胞胎的神经软体征总分高于对照组。未患病的不一致双胞胎的神经软体征总分显著高于对照双胞胎。未患病和患病的不一致双胞胎在神经软体征总分上存在显著差异。与对照组相比，不一致双胞胎中未患病和患病的双胞胎在身体左侧的神经软体征得分有升高趋势。
结论
这些结果表明，神经软体征的出现，尤其是其在身体左侧的偏侧化，是由基因传递的。
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