卡波西肉瘤疱疹病毒相关的卡斯特曼病伴POEMS综合征。

Kaposi's sarcoma herpesvirus-associated Castleman's disease with POEMS syndrome.

作者信息

Kim D E, Kim H J, Kim Y A, Lee K W

机构信息

Department of Neurology, College of Medicine, Seoul National University Hospital, 28 Yongon-dong, Chongno-ku, Seoul 110-744, Korea.

出版信息

Muscle Nerve. 2000 Mar;23(3):436-9. doi: 10.1002/(sici)1097-4598(200003)23:3<436::aid-mus18>3.0.co;2-i.

DOI:10.1002/(sici)1097-4598(200003)23:3<436::aid-mus18>3.0.co;2-i

PMID:10679723

Abstract

The pathogenic link between POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes, and various other clinical signs) syndrome and Castleman's disease is unclear. Roles for M protein in POEMS syndrome and cytokines in systemic manifestations of multicentric Castleman's disease have been suggested. Recently, pathogenic roles of cytokines in POEMS syndrome and Kaposi's sarcoma-associated herpesvirus (KSHV) in Castleman's disease have been reported. We report on a patient with KSHV-associated Castleman's disease with POEMS syndrome, and suggest a possible role of KSHV in initiating and linking these two diseases.

摘要

POEMS（多发性神经病、器官肿大、内分泌病、M蛋白、皮肤改变及其他各种临床体征）综合征与卡斯尔曼病之间的致病联系尚不清楚。有人提出M蛋白在POEMS综合征中的作用以及细胞因子在多中心卡斯尔曼病全身表现中的作用。最近，有报道称细胞因子在POEMS综合征中的致病作用以及卡波西肉瘤相关疱疹病毒（KSHV）在卡斯尔曼病中的致病作用。我们报告了1例伴有POEMS综合征的KSHV相关卡斯尔曼病患者，并提出KSHV在引发和联系这两种疾病中可能发挥的作用。