[Quantitative analysis of cAMP and cGMP in the plasma, iris and aqueous humor in rabbits with high intraocular pressure].

OBJECTIVE

To study the relationship between the levels of cyclic adenosine monophosphate (cAMP), cyclic guanosine monophos-phate (cGMP) in the plasma, iris and aqueous humor and high intraocular pressure in rabbits.

METHODS

The quantitative tests of cAMP and cGMP from rabbits were carried out by radioimmunoassay technique.

RESULTS

The results showed that there were 72.81 +/- 7.67, 141.08 +/- 16.70 and 28.40 +/- 0.49 of cAMP (nmol/L), and there were 10.37 +/- 6.15, 35.64 +/- 7.02 and 12.90 +/- 0.61 of cGMP (nmol/L) in the plasma, iris and aqueous humor respectively. The levels of cAMP were higher than those in the same samples from the animals as controls (P < 0.01), while the levels of cGMP were less than controls (P < 0.01).

CONCLUSION

High intraocular pressure may be significantly associated with the levels of cAMP and cGMP.