类风湿关节炎中对糖氧化损伤的IgG产生的IgM反应与疾病活动之间的关联。

Association between IgM response to IgG damaged by glyoxidation and disease activity in rheumatoid arthritis.

作者信息

Lucey M D, Newkirk M M, Neville C, Lepage K, Fortin P R

机构信息

Department of Medicine, The McGill University Health Centre, and The Montreal General Hospital Research Institute, Quebec, Canada.

出版信息

J Rheumatol. 2000 Feb;27(2):319-23.

PMID:10685791

Abstract

OBJECTIVE

To determine the association of serum IgG advanced glycation endproducts (AGE) and IgM anti-IgG-AGE antibodies with clinical measurements of rheumatoid arthritis (RA) disease activity.

METHODS

The study group consisted of 62 patients with RA and 16 control patients with osteoarthritis. Patient derived variables included perceived disease activity (10 cm visual analog scale, VAS) and Health Assessment Questionnaire (HAQ) results. Clinical measures of RA activity consisted of tender and swollen joint counts and a physician evaluation of disease activity (by VAS) as well as history of nodules, bone erosions, Sjogren's syndrome, and vasculitis documented by chart review. Patient sera were evaluated for glucose, glycosylated hemoglobin, and presence of RF, IgG-AGE and IgM anti-IgG-AGE. The nitroblue tetrazolium colorimetric and aminophenyl boronic acid methods were used for measurement of IgG-AGE, along with an ELISA for measurement of IgM anti-IgG-AGE.

RESULTS

Significant correlations were found between the presence of IgM anti-IgG-AGE and clinical measurements of swollen joint count and physician VAS.

CONCLUSION

IgM anti-IgG-AGE appears to be associated with clinical measurements of RA activity and represents a new marker of more active disease in RA.

摘要

目的

确定血清IgG晚期糖基化终产物（AGE）和IgM抗IgG-AGE抗体与类风湿关节炎（RA）疾病活动度临床指标之间的关联。

方法

研究组由62例RA患者和16例骨关节炎对照患者组成。患者的变量包括感知到的疾病活动度（10厘米视觉模拟量表，VAS）和健康评估问卷（HAQ）结果。RA活动度的临床指标包括压痛和肿胀关节计数、医生对疾病活动度的评估（通过VAS）以及通过病历审查记录的结节、骨侵蚀、干燥综合征和血管炎病史。对患者血清进行葡萄糖、糖化血红蛋白以及RF、IgG-AGE和IgM抗IgG-AGE检测。采用硝基蓝四唑比色法和氨基苯硼酸法测定IgG-AGE，同时采用酶联免疫吸附测定法（ELISA）测定IgM抗IgG-AGE。